4-(2-Aminoethyl)piperidine, N2-BOC protected

4-(2-Aminoethyl)piperidine, N2-BOC protected - Names and Identifiers

Name	(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms	4-(BOC-AMINOETHYL)PIPERIDINE 4-(2-Boc-aminoethyl)piperidine 4-(2-BOC-AMINOETHYL) PIPERIDINE 4-(N-BOC-2-AMINOETHYL)PIPERIDINE 4-(2-BOC-AMINOETHYL)-1-PIPERIDINE TERT-BUTYL (2-PIPERIDIN-4-YLETHYL)CARBAMATE 4-(2-Aminoethyl)piperidine, 4-BOC protected 4-(2-Aminoethyl)piperidine, N2-BOC protected (2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS	165528-81-4
InChI	InChI=1/C12H24N2O2/c1-12(2,3)16-11(15)14-9-6-10-4-7-13-8-5-10/h10,13H,4-9H2,1-3H3,(H,14,15)

4-(2-Aminoethyl)piperidine, N2-BOC protected - Physico-chemical Properties

Molecular Formula	C12H24N2O2
Molar Mass	228.33
Density	0.971±0.06 g/cm3(Predicted)
Boling Point	337.3±15.0 °C(Predicted)
Flash Point	157.8°C
Vapor Presure	0.000106mmHg at 25°C
Appearance	Powder
pKa	12.86±0.46(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.459

4-(2-Aminoethyl)piperidine, N2-BOC protected - Risk and Safety

Hazard Symbols

Xi - Irritant

4-(2-Aminoethyl)piperidine, N2-BOC protected - Reference Information

use

4-(2-BOC-aminoethyl) piperidine is mainly used as a pharmaceutical intermediate, and it has been reported in the literature that it can be used to prepare SHP2 inhibitors.

preparation

the remaining oil is dissolved in 800 mL of 90% acetic acid and treated with 250 mg of catalyst (PtO2). The mixture was stirred in a hydrogen atmosphere at 35°C for 96 hours. The catalyst is removed by filtration and the solvent is evaporated. Dissolve the residue in water adjusted to pH 11 with 1N NaOH. The water layer was extracted with DCM 3 times. The organic layer was dried by Na2SO4 and the solvent was evaporated. The product crystallizes from the remaining oil at 4°C to give 4-(2-BOC-aminoethyl) piperidine (white solid; yield: 21.9g).

Last Update：2024-04-09 02:00:00